If a patient's serum contains anti-C, anti-e, anti-Fya, and anti-Jkb, what is the best source of donor blood?

The best source of donor blood for a patient who has serum containing anti-C, anti-e, anti-Fya, and anti-Jkb is the rare donor file. This is because each of these antibodies is associated with specific red blood cell antigens that are not commonly found in the general population.

Patients with multiple antibodies often require blood from donors who have a rare phenotype, which increases the likelihood that their red blood cells will be compatible with the patient’s antibodies. The rare donor file is a repository of such donors who have been typed for several antigens and are identified as having rare blood types or are phenotypically matched for certain antibodies.

Other options such as testing all units in current stock or testing 100 group O, Rh-negative donors do not guarantee that the necessary antigen-negative blood will be found. Group-compatible donors are also less likely to provide a match considering the complexity of the antibodies present in the patient’s serum. Therefore, the rare donor file is the most strategic choice in ensuring that the antigens required to avoid hemolytic reactions are present in the donor blood.