In a family HLA typing for stem cell donation, what is the expected B antigen in the third child given the parents' typings?

In a family HLA typing for stem cell donation, what is the expected B antigen in the third child given the parents' typings?

• A. A1
• B. A2
• C. B12
• D. B35

Answer: (D)

In the context of HLA typing for stem cell donation, understanding the inheritance of HLA antigens is essential. HLA (Human Leukocyte Antigen) typing is crucial in matching donors and recipients for transplants, as compatibility can significantly affect the success of transplant procedures. Each parent contributes one HLA allele to their child. Therefore, the child's HLA typing will be determined by the combination of alleles inherited from each parent. In a family where the parent's typings are known, such as the presence of specific B antigens, one can analyze which antigens may be present in the offspring. The HLA system has several loci, including the A, B, and DR loci, with numerous alleles at each locus. For example, antigens B12 and B35 may be considered in light of the typings of the parents and the possibility of inheritance patterns. If B35 is mentioned as the expected antigen for the third child, it implies that at least one parent must express this antigen, which makes it suitable for passing on to the child. Moreover, families can express certain antigens that may be more prevalent based on ethnicity or genetic backgrounds, so observing which specific antigens are present in the parents can offer clues about the child's expected H

In the context of HLA typing for stem cell donation, understanding the inheritance of HLA antigens is essential. HLA (Human Leukocyte Antigen) typing is crucial in matching donors and recipients for transplants, as compatibility can significantly affect the success of transplant procedures.

Each parent contributes one HLA allele to their child. Therefore, the child's HLA typing will be determined by the combination of alleles inherited from each parent. In a family where the parent's typings are known, such as the presence of specific B antigens, one can analyze which antigens may be present in the offspring.

The HLA system has several loci, including the A, B, and DR loci, with numerous alleles at each locus. For example, antigens B12 and B35 may be considered in light of the typings of the parents and the possibility of inheritance patterns. If B35 is mentioned as the expected antigen for the third child, it implies that at least one parent must express this antigen, which makes it suitable for passing on to the child.

Moreover, families can express certain antigens that may be more prevalent based on ethnicity or genetic backgrounds, so observing which specific antigens are present in the parents can offer clues about the child's expected H