What are leukoreduced blood products?

Leukoreduced blood products refer to blood components from which the majority of white blood cells (leukocytes) have been removed. This process is essential for several reasons. The removal of white blood cells reduces the risk of transfusion-related complications, such as febrile non-hemolytic transfusion reactions and immune system sensitization, particularly in patients requiring multiple transfusions, like those with chronic illnesses or undergoing certain treatments.

Leukoreduction can be accomplished through methods like filtration during the collection or processing of blood products. This ensures that the transfused blood is safer for recipients who may have sensitivities or other complications related to white blood cells. By reducing the leukocyte content, these blood products also help minimize the incidence of transfusion-related immunomodulation, which can lead to increased susceptibility to infections and other adverse reactions.

Thus, the correct understanding of leukoreduced blood products centers on their formulation, which prioritizes safety and effectiveness by specifically removing a majority of the white blood cells present in the original blood samples.