What condition is a cause for permanent deferral from blood donation?

A history of jaundice of uncertain cause is a cause for permanent deferral from blood donation due to the potential underlying infectious diseases that may be associated with liver damage or dysfunction. Jaundice signals that there are changes in the liver's function, and without a clear diagnosis, it poses a risk of transmitting an infectious agent that could be harmful to recipients of blood products. Blood donation agencies prioritize the safety of the blood supply, and conditions with uncertain risk profiles, like undiagnosed jaundice, lead to a more cautious approach.

While diabetes, residence in an endemic malaria region, and a history of therapeutic rabies vaccine have specific guidelines with varying deferral periods or risk assessments, they do not necessarily lead to permanent deferral. For instance, diabetes typically does not prevent individuals from donating blood as long as their condition is well-managed, and those who have lived in malaria regions may face temporary deferral depending on travel specifics and time elapsed since their return. Similarly, a rabies vaccine received for therapeutic reasons usually does not have a permanent deferral unless other contraindications are present.