What is the optimum storage temperature for cryoprecipitated AHF?

Cryoprecipitated AHF (Antihemophilic Factor) is a component derived from fresh frozen plasma and is crucial for treating conditions like hemophilia. The optimal storage temperature for cryoprecipitated AHF is -20 ˚C because this temperature effectively preserves the functional activity of the clotting factors, particularly factor VIII and fibrinogen, which are essential for normal coagulation.

At -20 ˚C, the cryoprecipitate remains stable and can be stored for longer periods without significant loss of efficacy. Keeping it at this temperature ensures that when it is thawed for use, the factor levels are adequate for patient treatment.

Other temperatures listed, such as 4 ˚C, would not be appropriate for long-term storage, as this could lead to degradation of the factors involved. Meanwhile, storing it at room temperature (such as 22 ˚C) would accelerate the deterioration of the product and compromise its effectiveness. Thus, -20 ˚C is indeed the best and optimum temperature for maintaining the integrity and usability of cryoprecipitated AHF.